Ribosomal frameshifting in RNA Viruses

In this project, we were primarily interesting in understanding the thermodynamic stability and solution structures of hairpin-(H)-type RNA pseudoknots that stimulate -1 ribosomal frameshifting in many plant and animal RNA viruses. ┬áMulti-dimensional NMR spectroscopy was used to solve the solution structures of these so-called “triple-helical” RNAs, exemplified by exquisite pseudoknot loop-helix base pairing that collectively contribute to functional and structural stability.