Our research interests fall under a common umbrella we term the chemical and physical biology of infectious disease. Work is ongoing in two primary projects: 1) transition metal homeostasis (metallostasis) in bacterial pathogens; 2) hydrogen sulfide (H2S) sensing and reactive sulfur species (RSS) in the major nosocomial pathogens, Staphylococcus aureus (MRSA), Enterococcus facaelis and Acinetobacter baumannii. We have also worked in the area of regulatory RNA structure and function, in viral translational frameshifting, and most recently in the replication of vertebrate coronaviruses, a complex group of viruses that are causative agents of Middle East Respiratory Syndrome (MERS) and COVID-19. Prof. Giedroc seeks a molecular-level understanding of macromolecular structure, dynamics and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, proteomic profiling and NMR structure determination.