Giedroc Group
Chemical and Physical Biology of Infectious Disease
Bioinorganic Chemistry • Biophysical Chemistry • Bioanalytical Chemistry

Infectious disease is a persistent threat to human health. There is an increasingly urgent need to develop new antimicrobial strategies that limit the impact of life-threatening bacterial pathogens. An improved understanding of bacterial adaptation to host-imposed stressors is critical to the development of these new strategies.

Our discovery-focussed research group is organized under a common umbrella we term the chemical and physical biology of infectious disease. Work is ongoing in two primary projects: 1) transition metal homeostasis (metallostasis) in bacterial pathogens; 2) hydrogen sulfide (H2S) sensing and reactive sulfur species (RSS) in the major nosocomial pathogens, Staphylococcus aureus (MRSA), Enterococcus facaelis and Acinetobacter baumannii. The Giedroc group seeks a molecular-level understanding of macromolecular structure, dynamics and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, proteomic profiling and NMR structure determination to advance these projects.

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Current Research

Metallostasis: Transition metal homeostasis in bacterial pathogens (project 1) In this project, our goal is to understand the molecular mechanisms of how cells regulate the intracellular bioavailability of essential transition metal ions, notably Cu, Mn and Zn among others. This process, termed metal homeostasis and resistance, represents an important battleground in human host-bacterial pathogen interactions… View Article

Past RNA research and other projects

Coronavirus Replication In this project (2007-2013), initiated as a collaborative project at Texas A&M University, we used the tools of biophysical chemistry, SHAPE and NMR spectroscopy to understand the structure and biological function of the very “tips” of the coronavirus genome, the 5′ and 3′ untranslated regions (UTRs) that direct the replication, subgenomic RNA (sgRNA)… View Article